Restoration of autophagy represents a potential therapeutic target for neurodegenerative disorders but factors that regulate autophagic flux are largely unknown. with GFP-Rab7. Conversely expression of the dominant negative mutant EGFP-Rab7-T22N increased the accumulation of autophagosomes under control conditions which gathered even more during trophic aspect withdrawal. There BTF2 is no vesicular co-localization between Rab7-T22N and… Continue reading Restoration of autophagy represents a potential therapeutic target for neurodegenerative disorders